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10项研究、三大疗法能否颠覆糖尿病“胰岛素注射”时代?

21ȫصĹ֮һϻָȫ򲡳껼ߵѾ2013 3.82ӵ4.15ڣԤƵ2040һֻӵ6.42ڡ

1ͺͲ2򲡻߶ԣעȵزѪǼDZֶΡȻⲻߴʹܻ࣬ᵼµѪǵȲ֢ˣѧһֱڳԶֲͬ;ѰܹȵעƷΪ̵򲡸ϸƷƷϸƷȲؽչ

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Nature Medicine &; Nature Biotechnology

 

25գڡNature Medicine͡Nature Biotechnologyϵ2ƪУѧṩһַʵȵϸֲһֲϣȵϸֲǰʵַװСУЩװϸڳµʱ򲡣ųⷴӦ

 

ʡѧԺѧϵDaniel G Anderson2ƪĵĹͬͨѶߡAndersonͬǼǰһ뷨װȵϸֲΪһֿеƷ

 

о֣ԱװϸӰǣҲǺ͵֮ķͨźǣνֲ鳤ද֮ջڽΧγ֯Ӷʹ豸ЧоŶӾ޸ĺΣʹ䲻߷Ӧڹһ800ĿоԱСͷ鳤දн˼ֲԣѡһֽ̼TMTD

 

оԱѡһǿϵͳСƷϵװTMTDȵϸֲСǻһΪǻڿռֲ֮ϸʼȵأӦѪˮƽܹоڼ䣨174죩ʹѪǴڿ֮¡

 

Cell

 

֮ԽоڸϸƣΪоʹõȵϸ̥ϸġ2014109գڡϸ־ϵһоУѧDouglas MeltonŶӳɹҵһֿԽ̥ϸתɿɲͷȵصĦϸķ

 

Douglas MeltonڵĶڻӤʱͱϳ򲡣Ů14ʱҲϳ򲡡˵ǵо10򲡣ͻƶԼǰδеġ ڣоԱƻڷ鳤දнһǵ²ϣ򲡻нٴ顣

 

Stem Cell

 

2015423գ߷ڡStem Cell־ϵһо֣С󣨷ǷС󣩽еٴǰУоԱ֣עʸϸMSCsͨСѪҺеѪˮƽˣЩЧʱ޵ġ

 

ѧƲ⣬MSCs䵽ȵУôȵƻӶһתMSCsͨȱһؼϸճӣΪHCELLɽ鵼ѪҺϸ֢֯λĹ鳲Ϊ˽MSCsע䵽߹λ㣬оСHCELL鳲ӣԽ׵ȵСʹװHCELLMSCsѪˮƽ

 

Stem Cell Reports

 

2015319գڡStem Cell Reports־ϵһо֤ʵϸֲͽҩԷdzЧظ2Сģ͵ؼǴл

 

ȣоԱιС֬ʳյ˷֡ȵطӦ½ԼѪǡ2򲡵СֲԴ̥ϸķװϸЩֲϸ˷ȵصĦϸӶȵԺǴл⣬ϸֲеĽҩСټأڵһƷظǴл

 

ϸΪȵϸDZԽϵͼٸƵ֢״δоԱǵ2СģͽһֲȵϸЧ

 

PLOS ONE

 

2015128գڡPLOS ONE־ϵһоУɻѧоԱƤϸƱӦǵȵطϸʹСѪˮƽָ

 

СоУȵطϸེңΧһ㣩棬ǷһĽṹԼѪҺӦµġ١ɷȵأڼµʱ𽥾СѪˮƽ⣬СѪǻָ֮Ѫˮƽһֱȶ

2

 

Science Translational Medicine

 

20151125գڡScience Translational Medicine־ϵһоУѧǶһʽ1򲡣T1DMƷչ˵һȫ顣ٴУڽܶ26ڸϸĻ󣬲ûظãЩϸڻڴһʱ䡣

 

оУѧûĵTϸTregsɼϵͳȵϸƻͬʱϵͳֿȾ141843Ļֳ߱4飬һȵTregsע䣬ٵ500Tregs26ڸTregsʾ4黼ȫãҶ25%ϸһ껹ڻڼ⵽

 

Nature

 

һTregsصо20151118շڡNature־ϡоԱȽ˽С򲡵С򲡵СϵͳǷ֣򲡵С֬֯쳣ˮƽĵTregs

 

ĵĵһSagar Bapat˵ͨTregs֢оTregs֬ۻЩϸﵽٽ㣬ȫ֬֯е֢ʱǿ֬ڻһЩڰۻȵصֿ

 

ѧͨЩϸҪһַֹTregsϸ֬ۻʱСʱγ4򲡡ͨΪTregs壬һЩ⡣

 

Scientific Reports

 

2015730շڡScientific Reports־һоУѧĿѧоTregs1СģеáTregsͨƻףT1DµıԿ׵ףIL-35ıǵĹܡ

 

ͨѶ߼һKailash Singhʿ˵Щõϸ1򲡵ڷչб仵ˣǵϸƻϸ⣬о֣뽡ȣIL-35Ũ1򲡻нϵͣIL-351зҪá

 

оԱʾ״оIL-35ֲͬСģУתȷ1򲡡ͬʱоһµĻƣTregsԼθıǵˡ

 

 

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Cell Host &; Microbe

 

2015211գڡCell Host &; MicrobeϵһоУһ33ӻ汻϶򲡷ոߵķӤչΪ3о3ʱЩͯ4򲡡

 

ҽԺRamnik XavierŶӷ֣4ͯڵľȺΧԽխϸͨδ򲡶ͯ25%ҡͬʱӵи֢ϸͣI򲡿ܷǰࡣоԱֻ֣4ͯ򲡣11ʼ塣΢ȶԤ򲡵һַʽ

 

Diabetes

 

2015127գڡDiabetesϵһоУԿζѧJohn MarchŶӻȡijЩзֵļ˾ܲһΪȸѪ-1GLP-1ϡ

 

ڻСijڣоԱ֣GLP-1һЩϸɸЩвȵصϸ3ÿ조áϸСѪˮƽȶ½30%˾ҲЧMarchdzֹۡǵĿһֺиϸҩƬIͺII򲡻ճáMarchΪҩ֮ڱ

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